Fig. 6.

Roughness of the orthosteric binding site for different conformational states of the β₂AR. a – d: orthosteric binding site in complex with inverse agonist timolol a and carazolol b, antagonist alprenolol c and agonist d. Residues in direct contact with the ligand are shown in surface whereas residues within 4.5 Å but not in direct contact are shown in licorice