Table 3.

Average roughness of the β₂AR in different conformational states accompanied by the standard deviation (SD) for the orthosteric and the cholesterol binding sites at TM4

	3D4S	2RH1	3NYA	3P0G
Complete receptor (exposed residues)	2.1215 ± 0.0347	2.1210 ± 0.0363	2.1227 ± 0.0416	2.1196 ± 0.0352
Orthosteric binding site Trp1093.28, Asp1133.32, Val1143.33, Val1173.36, Ser2035.42, Phe2896.51, Phe2906.52, Asn3127.39, Tyr3167.43	2.1567 ± 0.0501	2.1521 ± 0.0424	2.1572 ± 0.0577	2.1592 ± 0.0367
Cholesterol binding site (TM4) Val812.52, Phe1083.27, Ile1123.31, Leu1153.34, Ile1544.46, Trp1584.50	2.1424 ± 0.0400	2.1430 ± 0.0411	2.1679 ± 0.0317	2.1303 ± 0.0394