Fig. 1.

Study flowchart. The mice were divided into four groups: Group 1 (control, no treatment), Group 2 (ALI, early multiple doses of Epo), Group 3 (ALI, early single high dose of Epo), Group 4 (CLI, late multiple doses of Epo). Large arrows mean injection of 5,000 U/kg Epo and small arrows 1,000 U/kg Epo. Five mice died before the end of the experiment. Epo, erythropoietin; G1, Group 1; G2, Group 2; G3, Group 3; G4, Group 4; ALI, acute limb ischemia; CLI, chronic limb ischemia; POD, postoperative day.