TABLE 1.

Clinical characteristics in female with melancholic versus nonmelancholic patients with MD

Characteristics	Melancholic n = 1,602; 81.3%	Nonmelancholic n = 368; 18.7%	OR	95% CI	P-value
Age	45.5 ± 8.8	43.4 ± 8.7	1.03	1.01–1.01	.003
Age of onset, years	36.2 ± 10.0	34.3 ± 9.5	1.02	1.01–1.03	.003
Number of episode	4.4 ± 5.4	3.5 ± 3.1	1.06	1.02–1.09	.005
Length of longest episode	46.7 ± 91.2	49.5 ± 93.5	1.00	0.99–1.00	.60
No. of DSM-IV A criteria	8.5 ± 0.8	7.2 ± 1.4	2.75	2.43–3.10	<.001
Feeling irritable	1,172 (71.3)	244 (73.5)	0.99	0.76–1.30	.96
Feeling hopeless	1,326 (83.0)	213 (64.2)	2.72	2.10–3.53	<.001
Crying	1,060 (66.4)	202 (60.8)	1.27	0.99–1.62	.06
Feeling helpless	1,437 (89.9)	266 (80.1)	2.22	1.62–3.03	<.001
Feeling nervous	1,451 (90.8)	279 (84.0)	1.88	1.34–2.63	<.001
No known precipitant	1,054 (66.0)	229 (69.0)	0.87	0.67–1.12	.30
Functional impairment	1,386 (87.0)	230 (69.5)	2.93	2.22–3.86	<.001
Neuroticism	12.7 ± 6.1	11.0 ± 5.9	1.05	1.03–1.07	<.001
Family history of MD	513 (33.1)	112 (31.9)	1.06	0.82–1.35	.70

Odds ratios (OR), P-values, and 95% confidence intervals (95% CI) are shown for clinical features of MD. ORs greater than one indicate that the clinical feature or symptom is more common in patients with melancholia. ORs less than one indicate that the clinical feature or symptom is less common in melancholic patients. MD, major depression.