Table 2.

ORs and 95% CIs of CNS infections or sepsis in relation to PD: a nested case–control study in Sweden, 2001–07^a

		Diagnosis type
Variables	All cases (n = 18 648)	Primary diagnosis (n = 13 762)	Secondary diagnosis only (n = 4886)
CNS infections
No	1.0 (ref.)	1.0 (ref.)	1.0 (ref.)
Yes	1.5 (1.2–1.9)	1.3 (1.0–1.8)	1.9 (1.3–2.8)
Years before the index date (years)
<1	3.0 (1.6–5.7)	2.3 (1.0–5.7)	4.0 (1.6–10)
1–4	1.7 (1.0–2.9)	1.5 (0.7–3.1)	2.0 (0.9–4.6)
5–9	1.3 (0.8–2.1)	1.4 (0.9–2.4)	1.0 (0.4–2.6)
≥10	1.2 (0.8–1.8)	1.0 (0.6–1.7)	1.8 (1.0–3.4)
Number of infections at least 5 years before the index date
Once	1.1 (0.8–1.6)	1.1 (0.8–1.7)	1.1 (0.6–2.1)
≥2 times	3.3 (1.4–8.2)	1.9 (0.5–7.1)	6.2 (1.7–23)
Duration of hospital stay at least 5 years before the index date (weeks)
<1	1.3 (0.8–2.1)	1.2 (0.7–2.1)	1.8 (0.7–4.5)
≥1	1.2 (0.8–1.8)	1.2 (0.7–1.9)	1.4 (0.7–2.6)
Sepsis
No	1.0 (ref.)	1.0 (ref.)	1.0 (ref.)
Yes	1.6 (1.4–1.7)	1.1 (1.0–1.2)	2.6 (2.3–2.9)
Years before the index date (years)
<1	3.5 (3.0–4.0)	1.7 (1.3–2.0)	7.2 (5.9–8.8)
1–4	1.2 (1.0–1.4)	0.9 (0.8–1.1)	1.8 (1.4–2.2)
5–9	1.0 (0.8–1.2)	0.8 (0.7–1.1)	1.3 (1.0–1.8)
≥10	1.0 (0.7–1.3)	1.1 (0.7–1.6)	0.8 (0.5–1.4)
Number of infections at least 5 years before the index date
Once	1.0 (0.8–1.1)	0.9 (0.7–1.1)	1.1 (0.8–1.4)
≥2 times	1.4 (0.8–2.4)	1.3 (0.6–2.9)	1.5 (0.7–3.2)
Duration of hospital stay at least 5 years before the index date (weeks)
<1	1.0 (0.7–1.2)	0.9 (0.7–1.3)	1.0 (0.7–1.6)
≥1	1.0 (0.8–1.3)	0.9 (0.7–1.2)	1.2 (0.9–1.7)

^aAdjusted for year of birth and gender.