Figure 1 .

Overview of the main analysis types available in oPOSSUM-3. The input for oPOSSUM can be either gene-based, which makes use of pre-computed results based on annotated genomic information, or sequenced-based, in which the user supplies the input sequences (e.g. ChIP-Seq results) for analysis. There are four methods available: (1) Single Site Analysis (SSA), (2) TFBS Cluster Analysis (TCA), (3) anchored Combination Site Analysis (aCSA), and (4) anchored TFBS Cluster Analysis (aCTCA). The first two methods apply enrichment analyses to individual TFs or TFBS clusters, whereas the latter two methods apply enrichment analyses to pairs of individual TFs or pairs of TFBS clusters. SSA and aCSA are depicted in this figure.