Table 3. Thermodynamic analysis of binding of the substrate and cofactor to Dat.
1 cal≈4.184 J.
Molecule | Ka (104 M−1) | Kd (μM) | ΔH (kcal/mol) | ΔS (cal/mol per K) | ΔG (kcal/mol) | n |
---|---|---|---|---|---|---|
Dopamine | 3.88±0.26 | 25.9±2.5 | −7.85±0.17 | −5.32 | −6.26 | 1.03±0.03 |
AcCoA | 18.8±2.6 | 5.43±1.09 | −11.5±0.3 | −14.4 | −7.20 | 0.88±0.01 |