. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Bioessays. 2012 Jan 11;34(3):205–217. doi: 10.1002/bies.201100136

Table 1a.

Ion transporters implicated in cancer

Protein	Species	Reference
NaV1.5 sodium channel	Human	[93]
EAG-1 potassium channel	Human	[94]
KCNK9 potassium channel	Mouse	[95]
Ductin (proton V-ATPase component)	Mouse	[96]
SLC5A8 sodium/butyrate transporter	Human	[97]
KCNE2 potassium channel	Mouse	[98]

Several ion transporters are now recognized as causal agents in carcinogenesis, consistent with the role of V_mem in regulating cell proliferation, migration, and differentiation. Future work remains to test the hypothesis that the patterning roles of voltage gradients are an important component of pattern disregulation as a fundamental cause of neoplasia [99, 100].