Table 5.

Supportive care for the management or prevention of adverse events associated with lenalidomide

Averse event	Supportive care
Neutropenia	G-CSF
Anemia	Red cell transfusion; start of erythropoietin†
Thrombocytopenia	Platelet transfusion
Diarrhea	Loperamide
Rash	Limited, localized rash: antihistamines and topical steroids Mild but extensive rash: short course of low-dose prednisone
VTE	Thromboprophylaxis (aspirin for patients at standard risk for VTE and LMWH or adjusted-dose warfarin in high-risk patients) is indicated when lenalidomide is combined with dexamethasone or cytotoxic agents

Note:

^†Concomitant use of erythropoietin with lenalidomide-based combinations may increase risk of VTE.

Abbreviations: G-CSF, granulocyte-colony stimulating factor; VTE, venous thromboembolism; LMWH, low molecular weight heparin.