Table 4.
Quality of life studies in PIDD patients switching to SCIG therapy
| Year: country | Comparison groups | Outcomes | Preference |
|---|---|---|---|
| 1995 Sweden, | SCIG hospital vs | Non-standardized questionnaires: high level of general satisfaction | 92% preferred SCIG |
| Norway, Denmark73 | SCIG at home | with SCIG at home, increased feeling of independence | over IMIG or IVIG |
| 2002 Sweden60 | SCIG at home | High level of satisfaction with rapid SCIG infusion | 92% continued rapid SCIG |
| 2004 Europe27 | SCIG at home vs IVIG hospital | Statistically significant improvements in general health perception, parental emotional impact, family activities, and global health. (CHQ-PF50) vitality, mental health and social functioning (SF-36) and improved satisfaction with IG therapy (Life Quality Index) for SCIG |
73% preferred SCIG |
| 2006 North America29 | A: SCIG at home vs IVIG hospital B: SCIG home vs IVIG at home | Statistically significant improvements in physical limitations, general health, vitality, health transition, LQI/treatment satisfaction (A); general health (B) SCIG | 81% (A), 69% (B) preferred SCIG |
| 2006 Germany82 | SCIG at home vs IVIG hospital/clinic | Non-standardized questionnaire mailed to patients: treatment satisfaction higher with SCIG, perceived increase in inconvenience of SCIG for patients on IVIG | 1/33 patients went back to IVIG during study |
| 2008 Sweden81 | SCID at home vs IVIG hospital | Statistically significant improvements in mental health, change in health, family activities and global health at 6 months (CHQ-PF50) | All subjects preferred home SCIG |
| 2010 North America37 | SCIG at home vs IVIG clinic | Statistically significant improvements in general health at 6 and 12 months and vitality at 6 months | Not reported |
| 2010 Germany83 | SCID at home vs IVIG hospital | Statistically significant improvements in bodily pain, general health perception, vitality (SF-36), family activities, parental emotional and time, general health | 92% preferred SCIG 83% preferred home treatment |
| 2011 Germany39 | SCID at home vs IVIG hospital | Health-related Quality of Life, LQI improved in SCIG, significant increase in score for convenience | 80% preferred SCIG |
Abbreviations: PIDD, primary immunodeficiency diseases; SCIG, subcutaneous immunoglobulin; CHQ-PF50, Child Health Questionnaire - Parent Form 50; IVIG, intravenous immunoglobulin; IMIG, intramuscular immunoglobulin; LQI, Life Quality Index.