Table 1.

EDRN Cohort Subject and Disease Characteristics

	All Cases		TMA Cases			RPPA Cases			QPCR Cases
	n=154			n=58	P*		n=67	P*		n=50	P*
Gender
Male	110	71.4%	41	70.7%	0.88‡	48	71.6%	0.96‡	36	72.0%	0.91‡
Female	44	28.6%	17	29.3%		19	28.4%		14	28.0%
Ethnicity
White	148	96.1%	57	98.3%	0.41∥	65	97.0%	0.69∥	51	98.1%	0.66∥
Non-white	6	4.4%	1	4.4%		2	4.4%		1	4.4%
Age, years
Median (Range)	58 (23–89)		61 (23–80)		0.42§	58 (23–80)		0.76§	60 (23–80)		0.44§
Smoking Status
Never smoker	24	15.6%	6	10.3%	0.20‡	9	13.4%	0.79‡	6	12.0%	0.65‡
Former smoker	50	32.5%	23	39.7%		23	34.3%		16	32.0%
Active Smoker	80	51.9%	29	50.0%		35	52.2%		28	56.0%
Cigarette Pack-Years
Never smoker	24	15.6%	6	10.3%	0.16‡	9	13.4%	0.42‡	6	12.0%	0.45‡
1–59 py	57	37.0%	18	31.0%		21	31.3%		17	34.0%
≥60 py	58	37.7%	26	44.8%		28	41.8%		22	44.0%
Unknown	15	9.7%	8	13.8%		9	13.4%		5	10.0%
Alcohol Drinker
Never drinker	40	26.0%	16	27.6%	0.72‡	18	26.9%	0.82‡	14	28.0%	0.69‡
Ever drinker	114	74.8%	42	74.8%		49	74.8%		36	74.8%
Alcohol Quantity†
Never drinker	40	26.0%	16	27.6%	0.85‡	18	26.9%	0.43‡	14	28.0%	0.08‡
1–4	48	31.2%	16	27.6%		18	26.9%		9	18.0%
≥5	46	29.9%	19	32.8%		24	35.8%		20	40.0%
Unknown	20	13.0%	7	12.1%		7	10.4%		7	14.0%
Tumor Type
Neck Metastasis	2	1.3%	2	3.4%	.15∥	2	3.0%	.30∥	1	2.0%	.28∥
New Primary	11	7.1%	2	3.4%		3	4.5%		1	2.0%
Primary	128	83.1%	50	86.2%		57	85.1%		43	86.0%
Recurrence	13	8.4%	4	6.9%		5	7.5%		5	10.0%
Tumor Site
Oral Cavity	70	45.5%	23	39.7%	.32∥	27	40.3%	.23∥	16	32.0%	.06∥
Oropharynx	29	18.8%	12	20.7%		12	17.9%		12	24.0%
Hypopharynx	11	7.1%	2	3.4%		3	4.5%		2	4.0%
Larynx	40	26.0%	19	32.8%		22	32.8%		18	36.0%
Neck	4	2.6%	2	3.4%		3	4.5%		2	4.0%
Disease Stage
I	26	16.9%	6	10.3%	.09∥	6	9.0%	.049∥	5	10.0%	.45∥
II	21	13.6%	11	19.0%		13	19.4%		7	14.0%
III	30	19.5%	7	12.1%		10	14.9%		8	16.0%
IV	61	39.6%	27	46.6%		30	44.8%		23	46.0%
Recurrence/Metastasis	15	9.7%	6	10.3%		7	10.4%		6	12.0%
Unknown	1	0.6%	1	1.7%		1	1.5%		1	2.0%
Treatment
RT Only	41	26.8%	19	32.8%	.43∥	20	29.0%	.73∥	18	36.0%	.16∥
CRT	27	17.6%	10	17.2%		11	15.9%		9	18.0%
No CRT	79	51.6%	27	46.6%		35	50.7%		21	42.0%
Unknown	6	3.9%	2	3.4%		3	4.3%		2	4.0%
Vital Status
Alive	79	51.3%	26	44.8%	0.15‡	30	44.8%	0.12‡	20	40.0%	0.04‡
Dead	73	47.4%	32	55.2%		37	55.2%		30	60.0%
Unknown	2	1.3%	0	0.0%		0	0.0%		0	0.0%
Time to Death, months
Median (Range)	44.6 (1.5–112.3)		42.2 (1.5–112.3)		0.44¶	42.5 (1.5–112.3)		0.21¶	44.2 (1.5–112.3)		0.21¶
Disease Progression Status
No disease progression	64	41.6%	22	37.9%		26	38.8%		16	32.0%
					0.41‡			0.46‡			0.08‡
Disease Progression	88	57.1%	36	62.1%		41	61.2%		34	68.0%
Unknown	2	1.3%	0	0.0%		0	0.0%		0	0.0%
Progression Free Survival, months
Median (Range)	33.8 (1.2–108.4)		26.4 (1.2–106.9)		0.51¶	26.8 (1.2–106.9)		0.40¶	24.8 (1.2–106.9)		0.28¶

^†Typical number of alcohol drinks in 2 week period

^‡Chi square test

^§Rank sum test

^∥Fisher's exact test

^¶Log rank test

^*Analyzed versus unanalyzed cases