Figure 6.
DPCPX increased wakefulness. Microinjection of the adenosine A1 receptor antagonist DPCPX into the prefrontal cortex caused a significant (*p < 0.0001 by Student's t test) increase in wakefulness and decrease in NREM sleep (A). The EEG power spectra did not differ following microinjection of saline and DPCPX during waking (B), NREM sleep (C), or REM sleep (D). EEG data were analyzed in 0.5 Hz increments and represent the average from eight mice. The insets show 10 s EEG and EMG recordings after microinjection of DPCPX.