The following three corrections do not affect the results, discussion, figures, and conclusions in our paper: Page 3596. Eq 26 in the original paper should read
 |
where η = cv is the packing fraction of the hard-sphere, c its molarity, and v its molar volume.
Second, in a one-component gas, the volume of the particles (v) is not given by the partial molar volume but by the van der Waals volume. It equals the volume of spheres with radii of 1.4, 2.33, and 2.66 Å for water, urea, and TMAO, respectively.1 Third, the shape of TMAO was previously approximated by a hard-sphere. However, an ellipsoid with semiaxes with a ratio of 1:1.6:1.8 is a better approximation for TMAO dihydrate. Then, we must use an equation of state for ellipsoids2 in calculating eq 26. It is given by 1 + (ZHS – 1)B2/4, where ZHS is the hard-sphere equation of state3 and B2 the second virial coefficient for hard ellipsoids.4
Funding Statement
National Institutes of Health, United States
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