Table 4.
Odds ratio (OR) for case-control study of 10 gastric cancer (GC) susceptibility loci.
| Genes/SNP | Genotype | Cases N (%) | Controls N (%) | Co-Dominant Model | Overdominant Model | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| OR (95% CI) | p a | OR (95% CI) | p b | ||||
| DNMT1 | |||||||
| rs2114724 | CC | 132 (54.5) | 162 (56.2) | 1.00 | 0.22 | 1.00 | 0.27 |
| CT | 97 (40.1) | 101 (35.1) | 1.16 (0.81–1.68) | - | 1.23 (0.86–1.76) | - | |
| TT | 13 (5.4) | 25 (8.7) | 0.62 (0.30–1.27) | - | - | - | |
| rs2228611 | GG | 132 (54.5) | 160 (56.1) | 1.00 | 0.14 | 1.00 | 0.22 |
| AG | 97 (40.1) | 99 (34.7) | 1.18 (0.81–1.71) | - | 1.26 (0.87–1.80) | - | |
| AA | 13 (5.4) | 26 (9.1) | 0.58 (0.28–1.18) | - | - | - | |
| rs8101866 | TT | 130 (53.9) | 166 (56.5) | 1.00 | 0.17 | 1.00 | 0.19 |
| CT | 98 (40.7) | 102 (34.7) | 1.20 (0.83–1.74) | - | 1.27 (0.89–1.82) | - | |
| CC | 13 (5.4) | 26 (8.8) | 0.61 (0.30–1.26) | - | - | - | |
| rs16999593 | TT | 141 (58.3) | 196 (66.7) | 1.00 | 0.13 | 1.00 | 0.05 |
| CT | 89 (36.8) | 83 (28.2) | 1.47 (1.01–2.14) | - | 1.45 (1.00–2.11) | - | |
| CC | 12 (5.0) | 15 (5.1) | 1.14 (0.51–2.54) | - | - | - | |
| DNMT2 | |||||||
| rs11254413 | GG | 204 (84.3) | 187 (63.8) | 1.00 | <0.0001 | 1.00 | <0.0001 |
| AG | 15 (6.2) | 91 (31.1) | 0.16 (0.09–0.28) | - | 0.15 (0.08–0.27) | - | |
| AA | 23 (9.5) | 15 (5.1) | 1.45 (0.73–2.90) | - | - | - | |
| DNMT3A | |||||||
| rs1550117 | GG | 157 (64.9) | 191 (65.0) | 1.00 | 0.74 | 1.00 | 0.68 |
| AG | 74 (30.6) | 93 (31.6) | 0.94 (0.64–1.37) | - | 0.92 (0.63–1.34) | - | |
| AA | 11 (4.5) | 10 (3.4) | 1.34 (0.55–3.29) | - | - | - | |
| rs11887120 | TT | 57 (23.6) | 74 (25.3) | 1.00 | 0.46 | 1.00 | 0.39 |
| CT | 121 (50.0) | 155 (53.1) | 0.96 (0.63–1.47) | - | 0.86 (0.61–1.22) | - | |
| CC | 64 (26.4) | 63 (21.6) | 1.26 (0.76–2.07) | - | - | - | |
| rs13420827 | CC | 167 (69.0) | 183 (62.7) | 1.00 | 0.046 | 1.00 | 0.034 |
| CG | 61 (25.2) | 99 (33.9) | 0.68 (0.46–1.01) | - | 0.66 (0.45–0.97) | - | |
| GG | 14 (5.8) | 10 (3.4) | 1.75 (0.74–4.14) | - | - | - | |
| rs13428812 | AA | 137 (56.6) | 160 (55.4) | 1.00 | 0.84 | 1.00 | 0.63 |
| AG | 84 (34.7) | 106 (36.7) | 0.93 (0.64–1.35) | - | 0.91 (0.64–1.31) | - | |
| GG | 21 (8.7) | 23 (8.0) | 1.11 (0.58–2.12) | - | - | - | |
| DNMT3B | |||||||
| rs2424908 | TT | 78 (32.2) | 99 (33.7) | 1.00 | 0.96 | 1.00 | 0.82 |
| CT | 114 (47.1) | 139 (47.3) | 0.98 (0.66–1.45) | - | 0.96 (0.68–1.36) | - | |
| CC | 50 (20.7) | 56 (19.1) | 1.05 (0.64–1.71) | - | - | - | |
Note: CI, confidence interval; OR, odds ratio; p-values obtained by chi-squared, OR (95% CI) was adjusted by sex and age; p
a
for codominant model, p
b
for overdominant model; Bold mean p < 0.05.