Table 5.
Multivariable-adjusted haplotype analysis of DNMT1 and DNMT3A genes and gastric cancer risk (n = 242).
| Genes | Haplotype | Frequencies | OR * (95% CI) | p Value | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Total | Control | Case | ||||
| DNMT1 | CGTT | 0.526 | 0.539 | 0.510 | 1.00 | - |
| TACT | 0.257 | 0.258 | 0.254 | 1.01 (0.76–1.36) | 0.93 | |
| CGTC | 0.211 | 0.192 | 0.234 | 1.24 (0.91–1.70) | 0.17 | |
| DNMT3A | CCAG | 0.268 | 0.276 | 0.255 | 1.00 | - |
| CTAG | 0.194 | 0.181 | 0.208 | 1.27 (0.80–2.01) | 0.31 | |
| CCGG | 0.105 | 0.086 | 0.130 | 1.47 (0.82–2.63) | 0.19 | |
Haplotypes were constructed from the following SNPs: rs2114724, rs2228611, rs8101866, rs16999593 on DNMT1, and rs13420827, rs11887120, rs13428812, rs1550117 on DNMT3A; Only haplotypes with ≥0.10 frequencies;
*
adjusted for age and sex.