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. 2012 Jul 6;13(7):8398–8429. doi: 10.3390/ijms13078398

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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High-mannose type glycan of influenza neuraminidase assists tetramer formation. (a) Overall structure of monomeric influenza N2 neuraminidase (PDB code; 1nn2). Protein, carbohydrate, and calcium ion are shown in ribbon, stick, and sphere models, respectively. (b) Tetrameric structure of influenza N2 neuraminidase (PDB code; 1nn2). N-linked glycans at Asn200 are shown in sphere models. The region delineated in black dotted lines is magnified in (c). (c) Close-up view of N-glycan at Asn200 and symmetry related molecule. Hydrogen bonds are shown in red dotted lines. (d) The side-chain torsion angles of Asn200 of N2, Asn207 of N6, and Asn200 of N9 NA (Asn201 in PDB code; 2b8h). (e) Amino acid sequence alignment of group 1 and 2 influenza neuraminidase around Asn200 glycosylation sites. Putative N-linked glycosylation sites in group 2 are highlighted.