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. 2012 Jul 6;13(7):8398–8429. doi: 10.3390/ijms13078398

Table 1.

Summary of Fc fragment structures.

PDB ID Glycan structure * Resolution Reference
Human IgG1 Fc fragment produced by HEK293T cell + kifunensine
2wah M7GN2 (chain-A) 2.51 [30]
M1GN2 (chain-B) - -
Human IgG1 Fc fragment by enzymatic treatment
1h3t M1GN2F 2.4 [31]
1h3u M3GN2F 2.4 enzymatic
1h3x GN2M3GN2F 2.44 treatment
1h3v G2GN2M3GN2F 3.1 [32])
1h3w G2GN2M3GN2F 2.82 -
1h3y G2GN2M3GN2F 4.1 -
Human IgG1 Fc produced by CHO or Fut8−/− CHO cells
3ave (2dtq) GN2M3GN2F 2.0 [29]
2dts GN1M3GN2 (chain-A) 2.2 -
GN2M3GN2 (chain-B) - -
Human IgG1 Fc fragment triple mutant (M252Y/S254T/T256E)
3fjt GN2M3GN2F 2.5 [33]
Human IgG1 Fc fragment triple mutant (L234F/L235E/P331S)
3c2s G1GN2M3GN2F 2.3 [34]
Protein is produced by HEK293 cells.
Human IgG1 Fc fragment triple mutant (S239D/A330L/I332E)
2ql1 G1GN2M3GN2F 2.5 [35]
Human IgG1 Fc fragment + 13 residues peptide
1dn2 G1GN1M3GN2F (chain-A) 2.7 [36]
G1GN2M3GN2F (chain-B) - -
Human IgG1 (Rituxan) Fc fragment + Staphylococcus aureus Protein A domain B
1l6x G2GN2M3GN2F 1.65 [37]
Human IgG1 Fc fragment
3do3 G1GN2M3GN2F 2.5 [38]
Human IgG1
1hzh G2GN2M3GN2F (chain-H) 2.7 [39]
G1GN2M3GN2F (chain-K) - -
Mouse IgG2a
1igt G1GN2M3GN2F 2.8 [19]
Human IgG1 Fc fragment + Protein-A mimetic peptide dendrimer.
3d6g GN2M3GN2F 2.30 [40]
Mouse IgG2b Fc fragment
2rgs GN2M3GN2F 2.1 [41]
Rabbit IgG Fc fragment
2vuo G1GN2M3GN2 1.95 [42]
Human IgG1 Fc fragment + minimized protein A
1oqo GN2M3GN2F 2.3 [43]
1oqx M3GN2F 2.6 -
Human IgG Fc fragment
1fc1 G1GN2M3GN2F 2.9 [17]
Rat IgG2a Fc fragment
1i1c GN2M3GN2F 2.7 [18]
Human IgG1 Fc fragment + human Fc receptor (FcγRIIIb)
1t83 (1its) G1GN1M3GN2F (chain-A) 3.0 [44]
GN2M3GN2F (chain-B) - -
1t89 (1iix) G1GN1M3GN2F (chain-A) 3.5 -
GN2M3GN2F (chain-B) - -
Human IgG1 Fc fragment + human Fc receptor (FcγRIIIb)
1e4k G1GN2M3GN2F 3.2 [45]
Human IgG1 Fc fragment + human Fc receptor (FcγRIIIa)
3sgj GN2M3GN2F 2.2 [46]
3sgk GN3M3GN2 2.4 -
Human IgG1 Fc fragment + human Fc receptor (FcγRIIIa)
3ay4 G1GN2M3GN2 2.2 [47]
Human heterodimeric Fc + human neonatal FcR (FnRn)
1i1a GN2M3GN2F 2.8 [18]
*

Glycan structures deposited in each PDB coordinate file are shown. G: d-galactose, GN: N-acetyl-d-glucosamine, M: d-mannose, F: l-fucose.