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. 2012 Jun 1;13(7):8500–8513. doi: 10.3390/ijms13078500

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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(A) The secondary metabolite gene cluster which encodes for the biosynthesis of coelibactin in Streptomyces coelicolor A3(2). Genes SCO7676-80 encode a ferredoxin (SCO7676, colored black) and four putative metal transport proteins (SCO7677-80). Genes SCO7681-92 encode the coelibactin biosynthetic pathway including the non-ribosomal peptide synthase genes (SCO7682, 7683, colored grey) which synthesise the initial coelbactin molecule which is then enzymatically tailored by CYP105N1 (SCO7686, colored black) and possibly by proteins of unknown function (SC7684, 7685, 7688 and 7692). SCO7689 and SCO7690 encode putative ABC transporters. (B) The predicted structure of coelibactin as determined by analysis of the sequence of the nonribosomal peptide synthetase (NRPS) proteins and prior to enzymatic tailoring.