Table 2.

Prediction success rate of ranking aggregation.

	Bound			Unbound/bound
Methods	TOP1	MCC * for TOP1	TOP3	TOP1	MCC for TOP1	TOP3
CON + DIS	57%	0.52	74%	61	0.53	74
VOL + DIS	52%	0.51	73%	54	0.53	74
CON + VOL	52%	0.52	72%	48	0.54	65
VOL + HYDRO	46%	0.50	67%	39	0.53	61
DIS + HYDRO	47%	0.51	68%	44	0.49	63
CON + HYDRO	53%	0.51	70%	39	0.53	61
DIS + CON + HYDRO	53%	0.50	72%	48	0.51	67
VOL + CON + HYDRO	51%	0.52	71%	41	0.55	63
VOL + DIS + HYDRO	50%	0.52	71%	46	0.50	67
VOL + DIS + CON	54%	0.51	73%	52	0.53	74
VOL + DIS + CON + HYDRO	53%	0.52	72%	48	0.53	67

^*The one-sided Wilcoxon signed ranked sum test is used based on the Matthews Correlation Coefficient (MCC) scores for each protein. The p values for the comparison of different methods are listed in the Supporting Information (Table S1 for bound test set, S2 for unbound/bound test set).