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. 2012 Jul 16;13(7):8762–8774. doi: 10.3390/ijms13078762

Figure 1.

Figure 1

The expression of miR-125b is down-regulated in both primary hepatocellular carcinoma (HCC) tissues and HCC cell lines. (A) Images of HCC tissues stained with haematoxylin and eosin (H&E). (B) Northern blot analysis indicating a marked decrease in miR-125b in six pairs of HCC tissues (HCC) relative to matching controls (NC). (C) Northern blot analysis demonstrating the remarkable decrease in miR-125b expression in the HCC cell lines (HepG2, Huh7, and SMMC7721) relative to normal liver tissue (NC). (D, E) Validation of the differential expression of miR-125b in amplified HCC tissues and control cells. Panel D illustrates the expression levels of miR-125b in an independently validated set of 32 HCC patients and matched controls. The levels of miR-125b expression were quantified by real-time RT-PCR and normalized using the non-tumor control sample. Panel E provides the statistical results regarding the miR-125b expression in HCC tissues and matched controls. The P values in this panel were calculated using a nonparametric test.