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. 2012 Jul 19;13(7):9014–9034. doi: 10.3390/ijms13079014

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Protective effect of a 50 mg/kg dose of Berberis vulgaris extract and Berberis vulgaris extract/βcyclodextrin on ultrastructure of hepatocytes against liver injuries induced by CCl4. (A) Control group; normal aspect of nucleus (N), glycogen deposits (G) and few lipid drops (L); (B) CCl₄ group; oedematous cytoplasm matrix with sER proliferation (asterix); dilated rER profiles (arrow) and enlarged nuclear space (arrowhead); increased number and size of lipid drops (L); (C) Berberis extract + CCl₄ group; normal aspect of nuclear shape (arrowhead) and rER (arrow);Mild reduction of number and size of lipid drops (L) and moderate recovery of glycogen deposits (G); (D) Berberis vulgaris extract/βcyclodextrin + CCl₄ group; Glycogen deposits recovery (G) and normal aspect of rER (arrow).

Protective effect of a 50 mg/kg dose of Berberis vulgaris extract and Berberis vulgaris extract/βcyclodextrin on ultrastructure of hepatocytes against liver injuries induced by CCl4. (A) Control group; normal aspect of nucleus (N), glycogen deposits (G) and few lipid drops (L); (B) CCl₄ group; oedematous cytoplasm matrix with sER proliferation (asterix); dilated rER profiles (arrow) and enlarged nuclear space (arrowhead); increased number and size of lipid drops (L); (C) Berberis extract + CCl₄ group; normal aspect of nuclear shape (arrowhead) and rER (arrow);Mild reduction of number and size of lipid drops (L) and moderate recovery of glycogen deposits (G); (D) Berberis vulgaris extract/βcyclodextrin + CCl₄ group; Glycogen deposits recovery (G) and normal aspect of rER (arrow).