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(A) The size and size distribution of plasmid DNA (pDNA), vesicles, and corresponding polyplexes – polyethylenimine (PEI)/pDNA and vesicle/pDNA. (B) The serum stability profile of the vesicles and PEI was evaluated by bovine serum albumin (BSA) measured by dynamic light scattering. (C) The scheme illustrating the mechanism of the surface properties on the stability of the PEI/BSA and vesicle/BSA polyplexes in aqueous solution.
