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. 2010 Spring;5(2):40–46.

Table 1.

Summary of the effects of zinc in pathophsiology and treatment of depression

Type of Study Zinc Concentration
Human studies:
 Depression ⇓ serum (35)
 Chronic depression (women) ⇓ serum (45)
 Postpartum depression ⇓ serum (46)
Animal tests/models:
 Depression+zinc treatment ⇑ brain (synaptic hippocampal zinc) (47)
 Forced swim test with Zinc treatment+antidepressant treatment ⇓ immobility (44)

⇓ Decrease ⇑ Increase