Figure 7.

NMDAR current is maximally activated by single evoked synaptic release events in stg but not WT RTN cells. Evoked NMDAR EPSCs (holding at +40 mV) after single stimulation (black) or train of five stimuli at 200 Hz (gray) in representative WT (Ai) and stg (Bi) RTN cells. Aii, Bii, NMDAR g–V plots for single (black squares) and train (white squares). The maximum conductance is increased greatly in WT cells from single to train responses (Aii) but not in stg (Bii) cells. C, Populations data showing ratio of conductance in train/single response of WT (black bar) and stg (white bar) pooled data. Dashed line indicates unity. *p < 0.05.