Table 4.
SIR for subsequent ischemic stroke of patients with IMD
| Follow-up interval (years) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
<1 |
1-5 |
5-10 |
> = 10 |
All |
|||||||||||||||
| Immune-mediated diseases |
O |
SIR |
95% CI |
O |
SIR |
95% CI |
O |
SIR |
95% CI |
O |
SIR |
95% CI |
O |
SIR |
95% CI |
|||||
| Addison´s disease |
14 |
2.71 |
1.48 |
4.56 |
28 |
1.17 |
0.78 |
1.69 |
30 |
1.90 |
1.28 |
2.72 |
11 |
0.97 |
0.48 |
1.74 |
83 |
1.48 |
1.18 |
1.83 |
| Amyotrophic lateral sclerosis |
7 |
0.53 |
0.21 |
1.10 |
16 |
1.52 |
0.87 |
2.47 |
7 |
1.77 |
0.70 |
3.67 |
2 |
1.15 |
0.11 |
4.23 |
32 |
1.09 |
0.74 |
1.54 |
| Ankylosing spondylitis |
8 |
1.62 |
0.69 |
3.21 |
44 |
1.55 |
1.13 |
2.08 |
24 |
0.98 |
0.63 |
1.46 |
35 |
1.08 |
0.75 |
1.50 |
111 |
1.23 |
1.01 |
1.48 |
| Autoimmune hemolytic anemia |
4 |
1.45 |
0.38 |
3.75 |
12 |
1.00 |
0.51 |
1.75 |
19 |
2.51 |
1.51 |
3.93 |
5 |
1.23 |
0.39 |
2.90 |
40 |
1.51 |
1.08 |
2.06 |
| Behcet´s disease |
1 |
4.00 |
0.00 |
22.93 |
1 |
0.65 |
0.00 |
3.70 |
0 |
|
|
|
1 |
1.43 |
0.00 |
8.19 |
3 |
0.78 |
0.15 |
2.29 |
| Celiac disease |
9 |
2.17 |
0.99 |
4.14 |
29 |
1.28 |
0.86 |
1.84 |
21 |
1.17 |
0.72 |
1.78 |
26 |
1.47 |
0.96 |
2.15 |
85 |
1.36 |
1.09 |
1.68 |
| Chorea minor |
0 |
|
|
|
1 |
2.27 |
0.00 |
13.03 |
0 |
|
|
|
0 |
|
|
|
1 |
1.11 |
0.00 |
6.37 |
| Crohn disease |
49 |
2.15 |
1.59 |
2.84 |
160 |
1.33 |
1.13 |
1.55 |
103 |
1.11 |
0.91 |
1.35 |
97 |
1.15 |
0.93 |
1.40 |
409 |
1.28 |
1.16 |
1.41 |
| Diabetes mellitus type I |
1 |
6.25 |
0.00 |
35.83 |
2 |
0.45 |
0.04 |
1.65 |
5 |
2.75 |
0.87 |
6.46 |
17 |
5.00 |
2.91 |
8.02 |
25 |
2.54 |
1.64 |
3.76 |
| Discoid lupus erythematosus |
3 |
4.23 |
0.80 |
12.51 |
3 |
0.99 |
0.19 |
2.92 |
1 |
0.47 |
0.00 |
2.70 |
3 |
1.55 |
0.29 |
4.60 |
10 |
1.28 |
0.61 |
2.37 |
| Grave´s disease |
101 |
2.15 |
1.76 |
2.62 |
402 |
1.39 |
1.26 |
1.53 |
348 |
1.36 |
1.22 |
1.51 |
276 |
1.27 |
1.12 |
1.43 |
1127 |
1.39 |
1.31 |
1.48 |
| Hashimoto´s thyroiditis |
77 |
2.99 |
2.36 |
3.74 |
211 |
1.73 |
1.50 |
1.98 |
115 |
1.39 |
1.14 |
1.67 |
82 |
1.28 |
1.02 |
1.59 |
485 |
1.64 |
1.50 |
1.80 |
| Immune thrombocytopenic purpura |
16 |
2.35 |
1.34 |
3.83 |
55 |
1.77 |
1.33 |
2.30 |
19 |
0.94 |
0.57 |
1.48 |
14 |
1.20 |
0.65 |
2.01 |
104 |
1.49 |
1.22 |
1.81 |
| Localized scleroderma |
2 |
1.28 |
0.12 |
4.71 |
13 |
1.25 |
0.66 |
2.14 |
18 |
1.72 |
1.01 |
2.72 |
11 |
1.04 |
0.51 |
1.86 |
44 |
1.33 |
0.97 |
1.79 |
| Lupoid hepatitis |
3 |
4.48 |
0.84 |
13.25 |
4 |
1.98 |
0.52 |
5.12 |
0 |
|
|
|
0 |
|
|
|
7 |
2.10 |
0.83 |
4.36 |
| Multiple sclerosis |
40 |
3.05 |
2.18 |
4.15 |
73 |
1.09 |
0.85 |
1.37 |
55 |
1.11 |
0.83 |
1.44 |
35 |
0.95 |
0.66 |
1.32 |
203 |
1.22 |
1.06 |
1.40 |
| Myasthenia gravis |
6 |
1.01 |
0.36 |
2.21 |
38 |
1.36 |
0.96 |
1.87 |
23 |
1.20 |
0.76 |
1.80 |
13 |
1.08 |
0.57 |
1.85 |
80 |
1.23 |
0.97 |
1.53 |
| Pernicious anemia |
25 |
1.56 |
1.01 |
2.31 |
138 |
1.49 |
1.25 |
1.76 |
89 |
1.23 |
0.99 |
1.52 |
74 |
1.44 |
1.13 |
1.80 |
326 |
1.40 |
1.25 |
1.56 |
| Polyarteritis nodosa |
5 |
1.23 |
0.39 |
2.89 |
20 |
1.30 |
0.79 |
2.02 |
11 |
1.05 |
0.52 |
1.88 |
10 |
1.13 |
0.54 |
2.08 |
46 |
1.19 |
0.87 |
1.58 |
| Polymyalgia rheumatica |
165 |
1.76 |
1.50 |
2.05 |
761 |
1.50 |
1.39 |
1.61 |
529 |
1.54 |
1.41 |
1.68 |
322 |
1.53 |
1.37 |
1.71 |
1777 |
1.54 |
1.47 |
1.61 |
| Polymyositis/ dermatomyositis |
10 |
3.46 |
1.65 |
6.39 |
13 |
1.19 |
0.63 |
2.03 |
6 |
1.07 |
0.38 |
2.34 |
5 |
1.73 |
0.55 |
4.07 |
34 |
1.52 |
1.05 |
2.13 |
| Primary biliary cirrhosis |
4 |
1.54 |
0.40 |
3.98 |
11 |
1.45 |
0.72 |
2.60 |
4 |
0.91 |
0.24 |
2.35 |
1 |
2.17 |
0.00 |
12.46 |
20 |
1.33 |
0.81 |
2.05 |
| Psoriasis |
44 |
1.92 |
1.39 |
2.58 |
217 |
1.65 |
1.44 |
1.89 |
163 |
1.53 |
1.30 |
1.78 |
144 |
1.41 |
1.19 |
1.66 |
568 |
1.56 |
1.44 |
1.70 |
| Reiter´s disease |
0 |
|
|
|
5 |
2.02 |
0.64 |
4.76 |
6 |
2.47 |
0.89 |
5.41 |
2 |
0.56 |
0.05 |
2.07 |
13 |
1.47 |
0.78 |
2.52 |
| Rheumatic fever |
5 |
3.91 |
1.23 |
9.19 |
10 |
1.66 |
0.79 |
3.06 |
14 |
3.04 |
1.65 |
5.11 |
7 |
1.81 |
0.72 |
3.75 |
36 |
2.28 |
1.59 |
3.16 |
| Rheumatoid arthritis |
345 |
2.08 |
1.86 |
2.31 |
1266 |
1.66 |
1.57 |
1.75 |
663 |
1.45 |
1.34 |
1.56 |
326 |
1.30 |
1.16 |
1.45 |
2600 |
1.59 |
1.53 |
1.65 |
| Sarcoidosis |
9 |
0.97 |
0.44 |
1.85 |
70 |
1.43 |
1.12 |
1.81 |
51 |
1.12 |
0.83 |
1.47 |
56 |
1.08 |
0.81 |
1.40 |
186 |
1.19 |
1.03 |
1.38 |
| Sjögren´s syndrome |
10 |
2.57 |
1.22 |
4.75 |
28 |
1.38 |
0.92 |
1.99 |
15 |
0.96 |
0.54 |
1.59 |
15 |
1.26 |
0.70 |
2.08 |
68 |
1.31 |
1.02 |
1.67 |
| Systemic lupus erythematosus |
19 |
2.21 |
1.33 |
3.46 |
88 |
2.33 |
1.87 |
2.87 |
54 |
1.92 |
1.44 |
2.51 |
30 |
1.26 |
0.85 |
1.80 |
191 |
1.94 |
1.68 |
2.24 |
| Systemic sclerosis |
11 |
1.90 |
0.94 |
3.41 |
28 |
1.22 |
0.81 |
1.77 |
11 |
1.19 |
0.59 |
2.14 |
2 |
0.39 |
0.04 |
1.43 |
52 |
1.21 |
0.90 |
1.58 |
| Ulcerative colitis |
71 |
2.15 |
1.68 |
2.71 |
231 |
1.27 |
1.11 |
1.45 |
162 |
1.09 |
0.92 |
1.27 |
146 |
1.05 |
0.89 |
1.24 |
610 |
1.21 |
1.12 |
1.31 |
| Wegener´s granulomatosis |
11 |
1.66 |
0.82 |
2.98 |
12 |
0.47 |
0.24 |
0.83 |
26 |
1.54 |
1.00 |
2.25 |
12 |
1.69 |
0.87 |
2.96 |
61 |
1.09 |
0.83 |
1.40 |
| All | 1075 | 2.02 | 1.90 | 2.14 | 3990 | 1.50 | 1.46 | 1.55 | 2592 | 1.38 | 1.33 | 1.43 | 1780 | 1.29 | 1.23 | 1.35 | 9437 | 1.46 | 1.43 | 1.49 |
O = observed number of cases; SIR = standardized incidence ratio; CI = confidence interval.
Bold type: 95% CI does not include 1.00.
Adjusted for age, period, socioeconomic status, region of residence, hospitalization of chronic lower respiratory diseases, obesity, alcoholism, hypertension, diabetes, atrial fibrillation, heart failure, renal disease, sepsis, and coronary heart disease.