Table 3.
GO function analysis of differential expressed genes at 48 h exposure of silver-NP-hydrogel
| Functional GO pathway | REF.-LIST*/Down- exp#/expected$ | P value |
|---|---|---|
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic processes |
3825/138/81.84 |
p = 8.40E-12 |
| cell cycle |
1840/62/39.37 |
p = 2.60E-04 |
| mitosis | 635/27/13.59 | p = 6.90E-04 |
* reference list, that is all genes number related to the GO pathway;
# down-expressed genes number in this study;
$ expected minimum genes number for activating of signal pathway.
Based on the gene ontology (GO) biological process, the GO pathway, which has theoretically significant activation (p < 1.0E-03), related to down-regulated genes.