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. Author manuscript; available in PMC: 2012 Aug 29.
Published in final edited form as: Nat Neurosci. 2011 Feb 6;14(3):357–365. doi: 10.1038/nn.2753

Figure 5. Reducing aberrant cerebellar activity or silencing cerebellar output lessons dystonia.

Figure 5

(a) Mice whose cerebella were chronically perfused with 36 ng/h ouabain showed clear signs of dystonia and were unable to walk on a treadmill at its lowest speed setting of 2 m/min. Acute injection of GABA into their cerebellum using the auxiliary port of the same canula used for ouabain perfusion reduced the severity of their dystonic postures such that, on average, the mice could walk on the treadmill at a pace of 5 m/min. (n=4; mean±s.e.m.)

(b) Deep cerebellar nuclei (DCN) were electrically lesioned in both cerebellar hemispheres at either at one or two sites (the two site lesion is shown here). Comparable data was obtained with both approaches. Scale bar corresponds to 1 mm.

(c) Chronic perfusion of 36ng/h ouabain into the cerebellum of DCN-lesioned mice did not produce dystonia. (n=7; mean±s.e.m.)