Table 4. In vivo toxin neutralization by mAb alone, pairs or triplex of mAbs.
mAbs | BoNT/B LD50 | Survival time (hours) | Survival (alive/tested) |
Control | 20 | <12 | 0/6 |
5G10 | 20 | 96 | 6/6 |
8E10 | 20 | 96 | 6/6 |
2F4 | 20 | 96 | 6/6 |
Control | 40 | <8 | 0/6 |
5G10 | 40 | 96 | 6/6 |
8E10 | 40 | 72 | 0/6 |
2F4 | 40 | 96 | 6/6 |
Control | 80 | <6 | 0/6 |
5G10 | 80 | 72 | 0/6 |
8E10 | 80 | 48 | 0/6 |
2F4 | 80 | 72 | 0/6 |
Control | 640 | <4 | 0/6 |
5G10+2F4 | 640 | 60 | 1/6 |
8E10+5G10 | 640 | 96 | 6/6 |
8E10+2F4 | 640 | 96 | 6/6 |
8E10+2F4+5G10 | 640 | 96 | 6/6 |
Control | 1280 | <3 | 0/6 |
5G10+2F4 | 1280 | 24 | 0/6 |
8E10+5G10 | 1280 | 96 | 3/6 |
8E10+2F4 | 1280 | 96 | 2/6 |
8E10+2F4+5G10 | 1280 | 96 | 3/6 |