Table 5. Pharmacokinetic parameters of the nine compounds in rat after oral administration of bu-yang-huan-wu-tang.
| Parameter | Cmax (ng/mL) | Tmax (min) | t1/2 (min) | AUC (min mg/mL) | Cl (mL/min/kg) |
| Astragaloside I | 55±7.8 | 40±16 | 166±28 | 16.6±2.6 | 90.5±14 |
| Astragaloside II | 30±4.9 | 37±6.8 | 212±14 | 11.4±2.3 | 129±15 |
| Astragaloside IV | 100±16 | 35±7.7 | 170±8.3 | 23.0±5.7 | 64.3±13 |
| Formononetin | 98±17 | 38±8.2 | 175±13 | 26.7±6.0 | 57.4±14 |
| Ononin | 19±4.5 | 35±7.7 | 134±9.6 | 4.6±1.0 | 351±47 |
| Calycosin | 1231±171a | 40±16 | 75±11 | 308±73b | 5.4±1.3 |
| Calycosin-7-O-β-D-glucoside | 18±4.1 | 32±6.1 | 338±132 | 3.25±0.7 | 428±143 |
| Ligustilide | 7.8±0.2 | 45±0.0 | 267±1.2 | 2.43±0.06 | 532±11 |
| Paeoniflorin | 97±33 | 35±7.7 | 93±32 | 21.0±3.9 | 76.5±15 |
Data expressed as mean ± standard error. (n = 6) Cmax: the maximum plasma concentration, t1/2: half-life, AUC: area under the concentration-time curve, Cl: clearance.
a
Significantly different (p<0.05) from the other active compounds in Cmax.
b
Significantly different (p<0.05) from the other active compounds in AUC.