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. 2012 Aug 29;7(8):e44217. doi: 10.1371/journal.pone.0044217

Figure 4. TβRIII−/− fetal thymi display an altered T cell development.

Figure 4

(A) Graph of thymocyte numbers at days 0, 3 and 7 from E14 TβRIII+/+ and TβRIII−/− fetal thymic lobes, respectively. (B) Representative CD4 versus CD8 staining dot plots from TβRIII+/+ and TβRIII−/− fetal thymic lobes at days 3 and 7 of culture. Summary of experiments showing the percentage of each thymocyte subsets from TβRIII+/+ and TβRIII−/− FTOCs at days 3 and 7. (C) Analysis of total cell numbers in gated DN, DP and CD4SP and CD8SP thymocytes from TβRIII+/+ and TβRIII−/− fetal thymi. Data are representative of three independent experiments. Mean values ± SEM are shown, TβRIII+/+ n  = 17 and TβRIII−/− n  = 16. Asterisks indicate *p≤0.05 and **p≤0.01.