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. 2012 Sep 4;79(10):1041–1048. doi: 10.1212/WNL.0b013e318268465b

Figure 3. Longitudinal evolution of metabolite ratios in patients with immune reconstitution inflammatory syndrome (IRIS) vs those without IRIS.

Figure 3

Metabolite/creatine (Cr) ratios obtained in progressive multifocal leukoencephalopathy (PML) lesions of patients with IRIS (solid dots) and patients without IRIS (white dots) up to 30 months after symptom onset are shown. (A) N-Acetylaspartate (NAA)/Cr ratios in patients with IRIS increase over time, but remain overall lower than those in the group without IRIS (not significantly different). (B) The choline (Cho)/Cr ratio decreases quickly over time in the group with IRIS, and after 30 months there is no difference between the groups with and without IRIS. (C) Myo-inositol (mI)/Cr ratios of patients with IRIS remain statistically significantly higher over time compared with those of patients without IRIS. (D) Lipid/lactate (Lip1)/Cr and (E) lipid/macromolecules (Lip2)/Cr ratios decrease quickly over time in the group with IRIS, and after 30 months there is no difference between the groups with and without IRIS.