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. 2012 Aug 29;7(8):e42719. doi: 10.1371/journal.pone.0042719

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© 2012 Dempere-Marco et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Mean field analysis of the model assessing the dependence of the network behaviour on the potentiated synaptic strength () and the inhibitory synaptic strength (), for different initial conditions. A The initial firing rate conditions for pools showing high firing rates are derived from a Gaussian distribution with mean = 40 Hz and standard deviation = 0.01 Hz. The firing rates determining the initial conditions of pools in spontaneous states are obtained from randomly sampling a Gaussian distribution with mean = 3 Hz and standard deviation = 0.01 Hz. The colour code indicates the number of pools which settle on stable states showing persistently high firing rates ( Hz) during the delay period when no further stimulation is provided. B Identical initial conditions as in A but one of the pools showing an initially high firing rate of 65 Hz. From left to right an increasing number of pools had high initial firing rates. Note that as a consequence of considering a hard boundary (i.e. Hz, used in subsequent studies) for values some apparent discontinuities may appear for increasing values, which in fact correspond to stable states with persistent firing rates just below the threshold. However, this does not occur in the region where our working point is located (, ).

Inline graphic — Mean field analysis of the model assessing the dependence of the network behaviour on the potentiated synaptic strength () and the inhibitory synaptic strength (), for different initial conditions. A The initial firing rate conditions for pools showing high firing rates are derived from a Gaussian distribution with mean = 40 Hz and standard deviation = 0.01 Hz. The firing rates determining the initial conditions of pools in spontaneous states are obtained from randomly sampling a Gaussian distribution with mean = 3 Hz and standard deviation = 0.01 Hz. The colour code indicates the number of pools which settle on stable states showing persistently high firing rates ( Hz) during the delay period when no further stimulation is provided. B Identical initial conditions as in A but one of the pools showing an initially high firing rate of 65 Hz. From left to right an increasing number of pools had high initial firing rates. Note that as a consequence of considering a hard boundary (i.e. Hz, used in subsequent studies) for values some apparent discontinuities may appear for increasing values, which in fact correspond to stable states with persistent firing rates just below the threshold. However, this does not occur in the region where our working point is located (, ).