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. Author manuscript; available in PMC: 2013 Jul 24.
Published in final edited form as: Circulation. 2012 Jun 15;126(4):468–478. doi: 10.1161/CIRCULATIONAHA.112.104380

Figure 5.

Figure 5

Effects of ROS scavenging and prevention of eNOS uncoupling on ex-vivo vascular function. Effects of acute BH4 supplementation on responses to acetylcholine (A) and sodium nitroprusside (B) in aortic tissue of 16 week old Ercc1d/− and WT mice. The acetylcholine responses after correction for individual responses to sodium nitroprusside (E). The effect of acute NAC supplementation on responses of Ercc1d/− to acetylcholine (C) and sodium nitroprusside (D). Acetylcholine responses expressed as % of the sodium nitroprusside response (F). †= p<0.05 (Mann-Whitney U test).