Table 1.
Association of the selected tag SNPs in the NER component with Pulse Wave Velocity.
| SNP | Chromosome
|
Allele
|
AortaGen Meta-analysis*
|
Closest Gene | ||||
|---|---|---|---|---|---|---|---|---|
| Number | Position | Coded | Frequency | Beta | SE | P value | ||
| Associations with P<1.61 × 10−4 | ||||||||
| rs2029298 | 11 | 47191294 | C | 0.30 | −0.05 | 0.01 | 1.04E-04 | DDB2 |
| Associations with 1.61 × 10−4<P<5.00 × 10−2 | ||||||||
| rs4772511 | 13 | 102369013 | T | 0.19 | 0.04 | 0.01 | 1.07E-02 | ERCC5 |
| rs4253002 | 10 | 50417344 | T | 0.02 | 0.13 | 0.05 | 1.53E-02 | ERCC6 |
| rs2340693 | 12 | 122700941 | G | 0.03 | −0.09 | 0.04 | 3.12E-02 | GTF2H3 |
| rs4150548 | 11 | 18304112 | A | 0.03 | 0.06 | 0.03 | 3.44E-02 | GTF2H1 |
| rs4253162 | 10 | 50361366 | T | 0.09 | −0.04 | 0.02 | 3.51E-02 | ERCC6 |
| rs3781619 | 11 | 47211893 | A | 0.13 | −0.03 | 0.02 | 3.80E-02 | DDB2 |
| rs50871 | 19 | 50554355 | A | 0.49 | −0.03 | 0.01 | 3.80E-02 | ERCC2 |
| rs9586010 | 13 | 102375850 | T | 0.26 | −0.03 | 0.02 | 3.90E-02 | ERCC5 |
| rs6488885 | 12 | 122685108 | G | 0.02 | −0.09 | 0.04 | 4.92E-02 | GTF2H3 |
Abbreviations: SNP, single nucleotide polymorphism; NER, Nucleotide Excision Repair; SE, standard error.
*
Coded allele is the minor allele. The analyses were adjusted for age, age2, sex, height and weight. The allele dose effect is the standard deviation of inverse carotid femoral pulse wave velocity (CFPWV) per coded allele. Because of the inverse transformation of CFPWV, a negative beta represents a higher CFPWV for each dose of the minor allele. For all of the SNPs in the table, N is 20634, except for rs2340693, rs9586010 and rs6488885 where N=16418.