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Inter-individual heterogeneity of pathology in animal models for PP-MS. TMEV infection and PP-EAE induced with MOG92-106. (a, b) Both in TMEV infection and PP-EAE, demyelination was observed in the spinal cord (arrowheads, Luxol fast blue stain). (c, d) Although a few oligodendrocytes survived in the lesions in TMEV infection (arrows), many oligodendrocytes were detected in PP-EAE (carbonic anhydrase II immunohistochemistry for oligodendrocytes). Magnification: × 70.
