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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Pathophysiology. 2012 May 26;20(1):71–84. doi: 10.1016/j.pathophys.2012.03.003

Table 6.

1-stage vs. 2-stage disease theories

Theory Clinical Pathology Neuroimaging Experimental Reference
1-stage RR-MS
PP-MS		 Inter-individual heterogeneity
Intra-individual homogeneity		 Gd (+) in RR-MS
Gd (−) in PP-MS		 Monophasic
EAE
RR-EAE		 [25;75] [26]
2-stage SP-MS
PR-MS		 Stage-dependent Gd (+) or (−) in SP-MS SP-EAE
TMEV		 [28]

Gd: gadolinium