TABLE 2.

Impact of dehydromonocrotaline (DMCT) toxicity and mild and severe pulmonary artery (PA) banding on right ventricular and right atrial calcium-handling proteins

	Sham (n=4)	DMCT (n=5)	Mild PA Band (n=5)	Severe PA Band (n=4)
Right Ventricle:
SERCA2a	1.00 ± 0.18	1.04 ± 0.09	0.78 ± 0.30	0.43 ± 0.18*
PLB	1.00 ± 0.10	1.19 ± 0.41	0.82 ± 0.19	0.84 ± 0.28
pPLB at serine-16	1.00 ± 0.16	0.82 ± 0.19	0.26 ± 0.30*	0.33 ± 0.20*
pPLB at threonine-17	1.00 ± 0.22	0.78 ± 0.32	0.63 ± 0.17*	0.70 ± 0.25*
Right Atrium:
SERCA2a	1.00 ± 0.14	1.14 ± 0.10	1.07 ± 0.23	0.81 ± 0.26
PLB	1.00 ± 0.18	1.00 ± 0.07	0.97 ± 0.24	0.72 ± 0.28
pPLB at serine-16	1.00 ± 0.23	0.88 ± 0.44	0.40 ± 0.39*	0.37 ± 0.34*
pPLB at threonine-17	1.00 ± 0.39	1.17 ± 0.22	0.90 ± 0.17	0.58 ± 0.29*

PLB, phospholamban; pPLB, phosphorylated PLB; SERCA2a, sarcoplasmic reticulum Ca²⁺-ATPase. Data are mean ± standard deviation normalized to GAPDH and Sham group.

^*P < 0.05 versus Sham (ANOVA, Fisher’s LSD test).