Table 1.
Description of genes and respective tagSNPs associated with colon and rectal cancer.
| Symbol | Chromosome | Alias | SNP | Major/Minor Allele | MAF1 | FDR HWE2 |
|---|---|---|---|---|---|---|
| JAK1 | 1p32.3-p31.3 | JAK1A | rs310211 | A /G | 0.31 | 1.00 |
| JAK1B | rs2256298 | C /T | 0.25 | 1.00 | ||
| rs3790541 | C /T | 0.11 | 1.00 | |||
| rs310199 | T /C | 0.29 | 1.00 | |||
| rs310198 | C /T | 0.11 | 1.00 | |||
| JAK2 | 9p24 | rs1887429 | G /T | 0.27 | 1.00 | |
| rs2274471 | T /C | 0.24 | 0.96 | |||
| rs7043371 | A /T | 0.50 | 1.00 | |||
| rs10974947 | G /A | 0.25 | 0.68 | |||
| rs3780379 | G /A | 0.19 | 0.62 | |||
| rs3780381 | A /C | 0.28 | 0.95 | |||
| rs10815160 | T /G | 0.24 | 0.87 | |||
| SOCS1 | 16p13.13 | CIS, CISH, JAB, SOCS-1 | rs4780355 | T /C | 0.30 | 0.96 |
| SSI-1, SSI1, TIP3 | rs193779 | G /A | 0.25 | 0.85 | ||
| SOCS2 | 12q | CIS2, Cish2, SOCS-2 | rs768775 | T /C | 0.19 | 0.68 |
| SSI-2, SSI2, STATI2 | rs3816997 | T /G | 0.14 | 1.00 | ||
| STAT1 | 2q32.2 | DKFZp686B04100 | rs3771300 | A /C | 0.49 | 1.00 |
| ISGF-3 | rs16824035 | C /T | 0.16 | 1.00 | ||
| STAT91 | rs4327257 | A /C | 0.14 | 1.00 | ||
| rs2280233 | A /G | 0.47 | 1.00 | |||
| rs2280232 | T /G | 0.26 | 1.00 | |||
| rs7562024 | C /T | 0.40 | 1.00 | |||
| rs10199181 | A /T | 0.38 | 1.00 | |||
| rs10208033 | T /C | 0.42 | 1.00 | |||
| STAT2 | 12q13.2 | ISGF-3, P113, STAT113, MGC59816 | rs2229363 | G /T | 0.01 | <.000001 |
| STAT3 | 17q21.31 | APRF | rs1053005 | A /G | 0.19 | 0.94 |
| FLJ20882 | rs2293152 | G /C | 0.40 | 0.98 | ||
| MGC16063 | rs6503695 | T /C | 0.34 | 0.96 | ||
| rs12949918 | T /C | 0.41 | 0.87 | |||
| rs1026916 | G /A | 0.35 | 0.97 | |||
| STAT4 | 2q32.2-q32.3 | rs4853540 | G /T | 0.21 | 0.96 | |
| rs3024904 | A /T | 0.11 | 1.00 | |||
| rs3024861 | T /A | 0.24 | 0.99 | |||
| rs10168266 | C /T | 0.19 | 1.00 | |||
| rs6752770 | A /G | 0.28 | 0.95 | |||
| rs11685878 | C /T | 0.40 | 0.95 | |||
| rs12327969 | G /C | 0.21 | 0.96 | |||
| STAT5A | 17q11.2 | MGF | rs7217728 | T /C | 0.28 | 0.03 |
| STAT5 | rs12601982 | A /G | 0.17 | 0.75 | ||
| STAT5B | 17q11.2 | STAT5 | rs9900213 | G /T | 0.16 | 1.00 |
| rs6503691 | C /T | 0.10 | 0.99 | |||
| rs7218653 | A /G | 0.29 | 0.74 | |||
| STAT6 | 12q13 | D12S1644 | rs3024979 | T /A | 0.11 | 1.00 |
| IL-4-STAT | rs324015 | G /A | 0.25 | 0.97 | ||
| STAT6B | rs3024974 | C /T | 0.10 | 1.00 | ||
| STAT6C | rs324011 | C /T | 0.39 | 0.90 | ||
| TYK2 | 19p13.2 | JTK1 | rs280519 | G /A | 0.48 | 0.98 |
| rs280521 | G /A | 0.14 | 1.00 | |||
| rs280523 | G /A | 0.07 | 0.87 | |||
| rs280500 | A /G | 0.15 | 1.00 |
1
Minor Allele Frequency (MAF) based on controls for non-Hispanic white population.
2
FDR (HWE) = False Discovery Rate adjusted p value for Hardy Weinberg Equilibrium test; HWE uses NHW controls.