Table 2.
Associations between JAK/STAT/SOCS-signaling pathway and colon and rectal cancer
| Colon Cancer | Controls | Cases | Wald p value | pACT | ||
|---|---|---|---|---|---|---|
|
| ||||||
| N | N | OR1 | (95% CI) | |||
| JAK2 (rs10815160) | 0.0332 | 0.1718 | ||||
| TT/TG | 1840 | 1431 | 1.00 | |||
| GG | 115 | 123 | 1.34 | (1.02, 1.76) | ||
| JAK2 (rs10974947) | 0.0403 | 0.1805 | ||||
| GG/GA | 1863 | 1457 | 1.00 | |||
| AA | 93 | 97 | 1.36 | (1.01, 1.82) | ||
| JAK2 (rs1887429) | 0.0294 | 0.1704 | ||||
| GG | 1019 | 866 | 1.00 | |||
| GT/TT | 921 | 686 | 0.86 | (0.75, 0.99) | ||
| JAK2 (rs3780379) | 0.0066 | 0.0479 | ||||
| GG/GA | 1905 | 1489 | 1.00 | |||
| AA | 51 | 65 | 1.68 | (1.16, 2.44) | ||
| SOCS2 (rs768775) | 0.0196 | 0.0384 | ||||
| TT | 1303 | 983 | 1.00 | |||
| TC/CC | 652 | 572 | 1.18 | (1.03, 1.36) | ||
| STAT1 (rs2280232) | 0.0116 | 0.1124 | ||||
| TT | 1056 | 900 | 1.00 | |||
| TG | 763 | 563 | 0.86 | (0.75, 0.99) | ||
| GG | 136 | 91 | 0.77 | (0.58, 1.02) | ||
| STAT1 (rs4327257) | 0.0319 | 0.2489 | ||||
| AA | 1462 | 1213 | 1.00 | |||
| AC/CC | 494 | 341 | 0.84 | (0.72, 0.99) | ||
| STAT3 (rs12949918) | 0.0170 | 0.0651 | ||||
| TT | 690 | 492 | 1.00 | |||
| TC/CC | 1266 | 1063 | 1.19 | (1.03, 1.37) | ||
| STAT3 (rs6503695) | 0.0032 | 0.0148 | ||||
| TT | 862 | 614 | 1.00 | |||
| TC | 871 | 735 | 1.19 | (1.03, 1.37) | ||
| CC | 223 | 206 | 1.32 | (1.07, 1.64) | ||
| STAT5A (rs7217728) | 0.0035 | 0.0065 | ||||
| TT | 974 | 699 | 1.00 | |||
| TC | 710 | 614 | 1.20 | (1.04, 1.39) | ||
| CC | 182 | 174 | 1.31 | (1.04, 1.66) | ||
| STAT5B (rs6503691) | 0.0068 | 0.0187 | ||||
| CC | 1555 | 1172 | 1.00 | |||
| CT | 365 | 336 | 1.20 | (1.01, 1.42) | ||
| TT | 36 | 47 | 1.59 | (1.00, 2.53) | ||
| STAT5B (rs7218653) | 0.0092 | 0.0181 | ||||
| AA | 998 | 727 | 1.00 | |||
| AG | 780 | 658 | 1.15 | (1.00, 1.33) | ||
| GG | 178 | 170 | 1.30 | (1.03, 1.64) | ||
| STAT6 (rs324015) | 0.0201 | 0.0751 | ||||
| GG | 1118 | 946 | 1.00 | |||
| GA/AA | 838 | 609 | 0.85 | (0.74, 0.97) | ||
| Summary Score2 | ||||||
| (0 – 5) | 271 | 157 | 1.00 | |||
| (6 – 7) | 292 | 203 | 1.19 | (0.91, 1.55) | ||
| (8 – 9) | 436 | 292 | 1.17 | (0.91, 1.50) | ||
| (10 – 11) | 426 | 341 | 1.37 | (1.08, 1.75) | ||
| (12 – 13) | 288 | 286 | 1.71 | (1.32, 2.21) | ||
| (14 – 23) | 243 | 276 | 2.00 | (1.54, 2.61) | ||
| P Trend | <.0001 | |||||
| Rectal Cancer | ||||||
| STAT3 (rs2293152) | 0.0138 | 0.0552 | ||||
| GG/GC | 791 | 655 | 1.00 | |||
| CC | 168 | 99 | 0.71 | (0.54, 0.93) | ||
| STAT4 (rs3024861) | 0.0416 | 0.4679 | ||||
| TT/TA | 857 | 690 | 1.00 | |||
| AA | 102 | 64 | 0.70 | (0.49, 0.99) | ||
| STAT6 (rs3024979) | 0.0163 | 0.0623 | ||||
| TT | 772 | 643 | 1.00 | |||
| TA/AA | 187 | 111 | 0.73 | (0.56, 0.94) | ||
| TYK2 (rs280500) | 0.0294 | 0.1255 | ||||
| AA | 708 | 523 | 1.00 | |||
| AG/GG | 250 | 231 | 1.27 | (1.02, 1.57) | ||
| Summary Score | ||||||
| (0 – 2) | 48 | 13 | 1.00 | |||
| (4 – 4) | 262 | 167 | 2.45 | (1.28, 4.67) | ||
| (6 – 6) | 496 | 423 | 3.27 | (1.74, 6.14) | ||
| (8 – 8) | 153 | 151 | 3.90 | (2.02, 7.52) | ||
| P Trend | <.0001 | |||||
1
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, center, race, and sex.
2
Summary Score is based on all SNPs showing independent effects