Table 5.
HRR from pathway SNPs associated with survival after diagnosis with colon or rectal cancer
| Summary Score | Death/Person Years | HRR1 | (95% CI) |
|---|---|---|---|
|
|
|||
| ColonCancer2 | |||
|
|
|||
| (0–7) | 31/1304 | 1.00 | |
| (8–9) | 36/985 | 2.41 | (1.47, 3.94) |
| (10–11) | 42/1487 | 1.70 | (1.06, 2.73) |
| (12–13) | 65/1530 | 2.49 | (1.60, 3.87) |
| (14–15) | 52/1212 | 2.63 | (1.67, 4.16) |
| (16–18) | 47/1061 | 2.57 | (1.61, 4.10) |
| (19–24) | 36/570 | 3.30 | (2.01, 5.42) |
| P Trend | <.0001 | ||
|
|
|||
| Rectal Cancer3 | |||
|
|
|||
| (0–4) | 19/729 | 1.00 | |
| (5–7) | 19/695 | 1.29 | (0.67, 2.49) |
| (8–10) | 33/842 | 1.97 | (1.11, 3.49) |
| (11–13) | 47/1074 | 1.62 | (0.94, 2.80) |
| (14–18) | 53/951 | 2.80 | (1.63, 4.80) |
| P Trend | <0.0001 | ||
1
Hazard Rate Ratios (HRR) and 95% Confidence Intervals (CI) adjusted for age, center, race, sex, AJCC stage, and tumor molecular phenotype
2
SNPs in colon cancer summary score: JAK2 rs10815160(A), rs10974947(D), rs1887429(A), rs3780379(A), and rs7043371(R), SOCS1 rs4780355(D), STAT3 rs1053005(D), rs2293152(R), and rs8069645(D), STAT5A rs12601982(D), TYK2 rs280521(D) and rs280523(D)
3
SNPs in rectal cancer summary score: JAK2 rs1536800(R), SOCS1 rs193779(D), STAT1 rs10199181(D), rs1547550(D), rs2280234(D) and rs7562024(A), STAT4 rs10168266(A) and rs16833260(D), TYK2 rs280519(D)