Figure I.

Overlapping classes and lists of the 76 endosome-associated scaffolds based on their binding properties. In humans, we identified 10 scaffolds that can bind to endosomal membrane (blue), 20 scaffolds that bind to endosome-related proteins (red), and 16 indirect endosomal scaffolds that interact with directly binding endosomal scaffolds (green). In addition, 29 scaffolds can bind both to endosome-related proteins and to directly binding endosomal scaffolds (red–green overlap). Only one scaffold hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) can bind both the endosomal membrane and endosome-related proteins (blue–red overlap). Scaffolds that are mentioned in the main text are highlighted.