Table 1.
Selected examples of predicted endosomal scaffolds and their crosstalking protein partners
| Scaffolda | Scaffold partner protein 1 | Scaffold partner protein 2 | ||
|---|---|---|---|---|
| Name | Pathway | Name | Pathway | |
| AXIN1 | TSC2 | RTK | PPP2CA | TGF, WNT |
| TSC2 | RTK | SMAD2 | TGF, WNT | |
| CTNNB | NOTCH, WNT | SMAD7 | TGF | |
| DVL1 | NOTCH, WNT | SMAD7 | TGF | |
| PIAS1 | NOTCH, JAK/STAT | SMAD7 | TGF | |
| CCNE1 | RB2 | TGF | CCND3 | WNT, JAK/STAT |
| RBL1 | TGF | HDAC1 | NOTCH | |
| RB2 | TGF | HDAC1 | NOTCH | |
| BRCA1 | NOTCH | E2F4 | TGF | |
| CCND3 | WNT, JAK/STAT | CDKN1B | RTK | |
| GRB1 | CTNNB | NOTCH, WNT | FLT | JAK/STAT |
| INSR | RTK | VAV | NOTCH, JAK/STAT | |
| JAK2 | JAK/STAT | ABL | NOTCH, RTK | |
| EGFR | RTK, JAK/STAT | CTNNB | NOTCH, WNT | |
| 50 more crosstalking partners for GRB1 are found in Table S2b in the supplementary material online | ||||
| SARA | ALK5 | TGF, RTK, JAK/STAT | CTNNB | NOTCH, WNT |
| CTNNB | NOTCH, WNT | SMAD7 | TGF | |
| ALK5 | TGF, RTK, JAK/STAT | MYL | NOTCH | |
a
For the complete list of the 49 predicted endosomal scaffolds able to mediate crosstalk, see Table S2b in the supplementary material online, where the proteins also contain hyperlinked UniProt ACs.