Table 1.
Baseline demographic characteristics and laboratory data in patients with different types of primary glomerulonephritis
| Demography and Biochemistry | Total (n=580) | FSGS (n=132) | IgAN (n=130) | MCD (n=109) | MN (n=209) | P Valuea |
|---|---|---|---|---|---|---|
| Age (years) | 44.4±16.8 | 44.3±15.1 | 34.5±12.1 | 35.7±15.9 | 55.2±14.3 | <0.001 |
| Male (%) | 58.5 | 57.6 | 46.9 | 63.3 | 63.6 | 0.02 |
| Diabetes (%) | 7.9 | 8.3 | 2.3 | 4.6 | 13.9 | 0.002 |
| Hypertension (%) | 32.5 | 48.5 | 25.4 | 21.1 | 33.0 | <0.001 |
| Serum albumin (g/dl) | 3.0±1.0 | 3.2±1.0 | 3.9±0.7 | 2.7±1.2 | 2.5±0.7 | <0.001 |
| Hemoglobin (g/dl) | 13.0±2.2 | 12.8±2.1 | 12.5±2.3 | 14.2±1.9 | 12.7±2.1 | <0.001 |
| BUN (mg/dl) | 22.9±17.6 | 30.1±20.3 | 24.2±22.2 | 19.7±13.0 | 19.0±12.3 | <0.001 |
| Serum creatinine (mg/dl) | 1.5±1.3 | 1.8±1.3 | 1.8±1.7 | 1.2±0.9 | 1.3±1.2 | <0.001 |
| eGFR (ml/min per 1.73 m2) | 70.4±33.8 | 56.8±33.7 | 63.4±32.7 | 87.3±34.0 | 74.6±29.6 | <0.001 |
| ≥90 (%) | 27.6 | 13.5 | 17.7 | 48.6 | 31.6 | <0.001 |
| 60–89 (%) | 34.1 | 25.6 | 35.4 | 33.1 | 39.7 | <0.001 |
| 30–59 (%) | 25.5 | 39.9 | 29.2 | 11.9 | 21.1 | <0.001 |
| 15–29 (%) | 8.8 | 16.5 | 8.5 | 4.6 | 6.2 | <0.001 |
| <15 (%) | 4.0 | 4.5 | 9.2 | 1.8 | 1.4 | <0.001 |
| Serum cholesterol (mg/dl) | 311±151 | 288±159 | 217±78 | 414±198 | 328±109 | <0.001 |
| Serum triglyceride (mg/dl) | 223±161 | 245±172 | 133±72 | 246±152 | 252±178 | <0.001 |
| Proteinuria | ||||||
| mild (1+ or 2+; %) | 28.7 | 31.1 | 56.3 | 25.9 | 11.6 | <0.001 |
| severe (>3.5g/d or ≥3+; %) | 71.3 | 68.9 | 43.7 | 74.1 | 88.4 | <0.001 |
| Steroid treatment alone (%) | 42.0 | 19.7 | 30.0 | 64.2 | 52.2 | <0.001 |
| Other cytotoxic agents alone (%) | 1 | 1 | 0 | 0 | 1 | |
| Combined treatment of steroid and cytotoxic agents (%) | 18.1 | 30.0 | 6.2 | 8.3 | 23.0 | <0.001 |
| Intervals between onset of disease and date of biopsy (days) | 12.7 | 10.3 | 10.7 | 12.8 | 15.4 | <0.001 |
FSGS, focal and segmental glomerulosclerosis; IgAN, IgA nephropathy; MCD, minimal change disease; MN, membranous nephropathy; eGFR, estimated GFR as calculated by the simplified Modification of Diet in Renal Disease formula: 186×(creatinine [mg/dl])−1.154×(age [years])−0.203×0.742 (if female).
a
All P values were obtained from one-way ANOVA for testing the equality in population means among the FSGS, IgAN, MCD, and MN groups of patients.