Table 3.

Associations of TCF7L2 SNPs with proinsulin/insulin ratios

SNP	MM/Mm/mm	Alleles M/m	MAF	M/M	M/m	m/m	p value	p valuea
rs12255372	999/844/201	G/T	0.31	0.98±0.56	1.08±0.65	1.21±0.74	1.7×10−7	1.2×10−7
rs7903146	992/843/213	C/T	0.31	0.98±0.56	1.07±0.65	1.21±0.72	1.2×10−7	8.6×10−8
rs10885406	527/1017/452	A/G	0.48	1.0±0.58	1.00±0.57	1.18±0.71	3.7×10−5	3.4×10−5
rs7924080	518/1028/452	T/C	0.48	0.99±0.54	1.01±0.59	1.17±0.72	4.5×10−5	4.2×10−5

The proinsulin/insulin ratios for each genotype are given as a means ± SD

Genotype counts by SNP are given: M, major allele; m, minor allele

The minor allele frequencies (MAF) are based on data from Framingham-unrelated participants

^ap values are adjusted for BMI