Table 1.
IC50 and EC50 values in E. coli reporter strains for the most active non-native AHLs in LasR and QscR.[a]
| Compound | IC50 [µm] | EC50 [µm] | ||
|---|---|---|---|---|
| QscR | LasR | QscR | LasR | |
| OdDHL | – | –[d] | 0.022[c] | 0.01[b] |
| DDHL | – | – | 0.005[c] | 0.04[b] |
| OOHL | – | 0.11[b] | 0.011[c] | –[d] |
| 1 | 0.030[c] | – | – | – |
| 2 | 0.13[c] | – | – | – |
| 3 | 0.16[c] | – | – | – |
| 4 | 0.18[c] | – | – | – |
| 5 | – | – | 0.056[c] | 0.01[b] |
| 6 | – | 0.25[b] | 0.006[c] | >200[b] |
| Q4 | 0.56[e] | – | – | – |
| Q5 | 0.11[e] | – | – | – |
| Q9 | 0.011 | – | – | – |
| Q10 | – | – | 1.1 | – |
| Q12 | 0.14[e] | – | – | – |
| Q13 | 0.22[e] | – | – | – |
| R1 | 1.9[e] | – | – | >200 |
| R4 | – | – | 2.0 | – |
| R5 | – | – | 0.89 | – |
| R6 | 0.057 | 1.0 | – | – |
| S1 | – | – | – | – |
| S2 | – | – | 0.10 | – |
| S3 | – | – | 0.079 | >200 |
| S6 | – | – | – | – |
| S7 | 0.020[e] | 10 | 0.078 | – |
[a]
For strain and assay information, see the Experimental Section. Determined by testing AHLs over a range of concentrations (10−2–105 nm). All assays were performed in triplicate; italicized compounds are controls.
[b]
Values reported previously, see ref. [24].
[c]
Values reported previously, see ref. [26].
[d]
Not determined.
[e]
Antagonism dose–response curve up-turned at higher concentrations; see the Supporting Information.