Figure 2.

Effect of conjugation inhibitors on the toxicity of 4BP to isolated rat hepatocytes. Plated cells were washed as described in Materials and Methods and then incubated with the indicated concentrations of 4BP ± inhibitors. Untreated (UT) control cells were incubated in medium lacking 4BP and inhibitors. At the indicated times aliquots of medium were withdrawn for analysis of LDH leakage. A) Effect of inhibitors alone. B–D) Effect of inhibitors on increasing concentrations of 4BP.