Table 2.

Covalent Binding of Bromobenzene vs. 4-Bromophenol in Liver vs. Isolated Hepatocytes.

#	Systema	Agent	Dose (mmol/kg)	Time (hr)	CVB (nmol-eq./mg protein)	Ref.
1	UT rat	4BP	3	10	0.23 ± 0.04	17
2	PB rat	4BP	1	5	0.25–0.42	this work
3	PB rat hepatocytes	4BP	0.25 mM	2	0.08, 0.11	39
4	UT rat	BB	3	10	0.37 ± 0.07	17
5	UT rat	BB	7.16	24	1.33 ± 0.11	3
6	3MC rat	BB	7.16	24	0.75 ± 0.03	3
7	UT mouse	BB	4.8	24	1.89	38
8	UT mouse	BB	6.53	16	2.5	38
9	UT mouse	BB	4.06	5	1.09	38
10	UT mouse	BB	4.06	24	2.52	38
11	UT mouse	BB	1.5	5	0.79 ± 0.14	38
12	PB mouse	BB	1.5	5	0.99 ± 0.23	38
13	UT rat	BB	10	5	2.3	4
14	PB rat	BB	2.5	4	0.68 ± 0.59	31
15	PB rat	BB	2.5	4	2.9	32
16	PB rat	BB	2	4	3.5–6.1	20
17	PB rat hepatocytes	BB	3 mM	2	2.9	39
18	PB rat hepatocytes	BB	5 mM	2	3.6	34

^aUT means untreated (uninduced); PB means pretreated (induced) with phenobarbital.