Figure 5.

Effect of ethyl acetate extract of Saussurea involucrata (SI-2) or rutin on plasma MDA level and SOD and GPx activities in D-galactose-treated (aged) mice. The control group received subcutaneous (s.c.) injections of phosphate-buffered saline. The aged group received D-galactose (300 mg/kg, s.c.). SI-2 + G-gal or rutin + G-gal groups received D-galactose (300 mg/kg/day, s.c.) plus SI-2 or rutin (30 mg/kg/day, p.o.). Treatments were administered for 6 weeks. (SI-2) and rutin treatment attenuated the aging characteristics of increased MDA level and downregulated SOD and GPx activities. Data are presented as mean ± standard deviation (SD) (n = 6 mice). *P < 0.05 versus the aged group.