Figure 3.

Administration of PGRN attenuated LPS-induced pulmonary inflammation. Groups of mice were challenged with LPS and treated with PGRN 30 min later. The tPGRN represented that PGRN was administered twice at 40 h intervals. (a-b) Total cell (a) and neutrophil (b) counts in BAL fluid were detected to evaluate lung airspace inflammation at day 3 after LPS challenge. (c and d) The indicated proinflammatory cytokines and chemokines in BAL fluid were determined at day 3 after LPS challenge. Data are represented as mean ± standard deviation of one experiment consisting of three replicates. Experiments were performed in triplicate. *P < 0.05.