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Proposed model for the ubiquitination and destruction of DEPTOR by SCFβ-TrCP. In low-energy state, DEPTOR inhibits mTOR activity. However, in high-energy state, mTOR as the priming kinase phosphorylates DEPTOR to trigger subsequent casein kinase-1 (CK1)-mediated phosphorylation of DEPTOR. Phosphorylation of DEPTOR by both mTOR and CK1 triggers SCFβ-TrCP-mediated ubiquitination of DEPTOR.
